Drug interactions
Clorazepate + Dantrolene
Severity: Moderate
Clorazepate and Dantrolene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dantrolene commonly causes drowsiness and dizziness, and clorazepate is a benzodiazepine with sedative and psychomotor-impairing effects. Taken together, central nervous system depression may be greater, raising the risk of excessive sedation, impaired coordination and falls.
What this interaction means in plain words
Clorazepate and Dantrolene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clorazepate belongs to Central Nervous System; Dantrolene belongs to Musculoskeletal.
Why it happens
Additive central nervous system depression from two drugs that each cause sedation.
What to do
Start with the lowest effective doses and monitor for excessive sedation and impaired psychomotor function. Advise patients to avoid driving and alcohol until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dantrolene
Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Frequently asked questions
Can I take Clorazepate with Dantrolene?
MediHelp rates the interaction as moderate. Clorazepate and Dantrolene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dantrolene commonly causes drowsiness and dizziness, and clorazepate is a benzodiazepine with sedative and psychomotor-impairing effects. Taken together, central nervous system depression may be greater, raising the risk of excessive sedation, impaired coordination and falls.
How serious is the interaction between Clorazepate and Dantrolene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with the lowest effective doses and monitor for excessive sedation and impaired psychomotor function. Advise patients to avoid driving and alcohol until the response is known.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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