Drug interactions
Clorazepate + Rucaparib
Severity: Minor
Clorazepate and Rucaparib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib is a weak inhibitor of CYP3A4, so it may modestly increase exposure to clorazepate's active metabolite. The clinical effect is generally small but could add to sedation.
What this interaction means in plain words
Clorazepate and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clorazepate belongs to Central Nervous System; Rucaparib belongs to Oncology.
Why it happens
Weak inhibition of CYP3A4 by rucaparib slightly reduces benzodiazepine metabolism.
What to do
No dose change is routinely needed; monitor for increased drowsiness and adjust the clorazepate dose if it occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Clorazepate with Rucaparib?
MediHelp rates the interaction as minor. Clorazepate and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib is a weak inhibitor of CYP3A4, so it may modestly increase exposure to clorazepate's active metabolite. The clinical effect is generally small but could add to sedation.
How serious is the interaction between Clorazepate and Rucaparib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is routinely needed; monitor for increased drowsiness and adjust the clorazepate dose if it occurs.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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