Drug interactions
Clorazepate + Stiripentol
Severity: Moderate
Clorazepate and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits several CYP enzymes and adds to the sedative effects of benzodiazepines, so somnolence and drowsiness are more likely, as seen with clobazam. Altered clorazepate metabolite exposure is possible and may affect seizure control or sedation.
What this interaction means in plain words
Clorazepate and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clorazepate belongs to Central Nervous System; Stiripentol belongs to Central Nervous System.
Why it happens
Additive CNS depression plus modulation of CYP3A4 and CYP2C19 metabolism by stiripentol.
What to do
Monitor for sedation and changes in seizure control, and reduce the clorazepate dose if excessive drowsiness occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Other interactions of Stiripentol
Frequently asked questions
Can I take Clorazepate with Stiripentol?
MediHelp rates the interaction as moderate. Clorazepate and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol inhibits several CYP enzymes and adds to the sedative effects of benzodiazepines, so somnolence and drowsiness are more likely, as seen with clobazam. Altered clorazepate metabolite exposure is possible and may affect seizure control or sedation.
How serious is the interaction between Clorazepate and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and changes in seizure control, and reduce the clorazepate dose if excessive drowsiness occurs.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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