Drug interactions
Clotrimazole + Elagolix
Severity: Minor
Clotrimazole and Elagolix: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elagolix is a substrate of the hepatic uptake transporter OATP1B1, and strong inhibitors markedly raise its exposure, which increases the risk of dose-related adverse effects such as bone loss and liver enzyme elevation. Clotrimazole is not a recognized strong OATP1B1 inhibitor, and topical or lozenge forms have limited systemic exposure, so the legacy classification looks overstated.
What this interaction means in plain words
Clotrimazole and Elagolix have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clotrimazole belongs to Anti Fungals; Elagolix belongs to Musculoskeletal.
Why it happens
Possible OATP1B1 inhibition by clotrimazole could raise elagolix levels, but this is not well established for clotrimazole.
What to do
No routine action is needed for topical clotrimazole. If systemic azole therapy is considered, review the elagolix dose and monitor liver tests.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clotrimazole
- Clotrimazole + Lomitapide Major
- Clotrimazole + Mavacamten Major
- Clotrimazole + Mobocertinib Major
- Clotrimazole + Voclosporin Major
- Bosutinib + Clotrimazole Moderate
- Cannabidiol + Clotrimazole Moderate
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Clotrimazole with Elagolix?
MediHelp rates the interaction as minor. Clotrimazole and Elagolix have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Elagolix is a substrate of the hepatic uptake transporter OATP1B1, and strong inhibitors markedly raise its exposure, which increases the risk of dose-related adverse effects such as bone loss and liver enzyme elevation. Clotrimazole is not a recognized strong OATP1B1 inhibitor, and topical or lozenge forms have limited systemic exposure, so the legacy classification looks overstated.
How serious is the interaction between Clotrimazole and Elagolix?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed for topical clotrimazole. If systemic azole therapy is considered, review the elagolix dose and monitor liver tests.
What other medicines interact with Clotrimazole?
MediHelp also lists interactions of Clotrimazole with, for example, Lomitapide, Mavacamten, Mobocertinib. The full list is on the Clotrimazole page.
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