Drug interactions
Clozapine + Ertugliflozin-sitagliptin
Severity: Moderate
Clozapine and Ertugliflozin-sitagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clozapine is strongly associated with hyperglycemia, insulin resistance and new-onset diabetes, which may undermine glucose-lowering therapy. Glycemic control can deteriorate and ketoacidosis has been reported with clozapine.
What this interaction means in plain words
Clozapine and Ertugliflozin-sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Ertugliflozin-sitagliptin belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism: antipsychotic-related insulin resistance and impaired glucose regulation.
What to do
Monitor fasting glucose and HbA1c regularly and intensify antidiabetic therapy as needed. Watch for ketoacidosis symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ertugliflozin-sitagliptin
Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Clozapine with Ertugliflozin-sitagliptin?
MediHelp rates the interaction as moderate. Clozapine and Ertugliflozin-sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clozapine is strongly associated with hyperglycemia, insulin resistance and new-onset diabetes, which may undermine glucose-lowering therapy. Glycemic control can deteriorate and ketoacidosis has been reported with clozapine.
How serious is the interaction between Clozapine and Ertugliflozin-sitagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose and HbA1c regularly and intensify antidiabetic therapy as needed. Watch for ketoacidosis symptoms.
What other medicines interact with Ertugliflozin-sitagliptin?
MediHelp also lists interactions of Ertugliflozin-sitagliptin with, for example, Albiglutide, Aripiprazole, Asenapine. The full list is on the Ertugliflozin-sitagliptin page.
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