Drug interactions
Clozapine + Givosiran
Severity: Moderate
Clozapine and Givosiran: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givosiran can reduce CYP1A2 activity, and clozapine is a sensitive CYP1A2 substrate. Clozapine concentrations may rise, increasing the risk of sedation, hypotension, seizures and other dose-related adverse effects.
What this interaction means in plain words
Clozapine and Givosiran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Givosiran belongs to Miscellaneous.
Why it happens
Givosiran reduces CYP1A2-mediated metabolism of clozapine, which raises clozapine exposure.
What to do
Monitor for clozapine toxicity and consider checking clozapine plasma levels after givosiran is started. Reduce the clozapine dose if levels are high or adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Other interactions of Givosiran
- Duloxetine + Givosiran Major
- Givosiran + Pimozide Major
- Givosiran + Propafenone Major
- Givosiran + Theophylline Major
- Givosiran + Thioridazine Major
- Givosiran + Tizanidine Major
Frequently asked questions
Can I take Clozapine with Givosiran?
MediHelp rates the interaction as moderate. Clozapine and Givosiran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Givosiran can reduce CYP1A2 activity, and clozapine is a sensitive CYP1A2 substrate. Clozapine concentrations may rise, increasing the risk of sedation, hypotension, seizures and other dose-related adverse effects.
How serious is the interaction between Clozapine and Givosiran?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for clozapine toxicity and consider checking clozapine plasma levels after givosiran is started. Reduce the clozapine dose if levels are high or adverse effects appear.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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