Drug interactions
Indomethacin + Vasopressin
Severity: Moderate
Indomethacin and Vasopressin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indomethacin may prolong and intensify the hemodynamic effects of vasopressin, including its effects on cardiac index and systemic vascular resistance. This can lead to a stronger or longer pressor response than expected.
What this interaction means in plain words
Indomethacin and Vasopressin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indomethacin belongs to Musculoskeletal; Vasopressin belongs to Endocrine.
Why it happens
Prostaglandin synthesis inhibition by indomethacin may reduce vasodilatory counter-regulation and alter vasopressin clearance, though the exact mechanism is not fully established.
What to do
Monitor blood pressure and hemodynamic parameters closely and titrate the vasopressin infusion to the desired response. Reduce the dose if an excessive pressor effect occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vasopressin
- Carbamazepine + Vasopressin Moderate
- Clomipramine + Vasopressin Moderate
- Clozapine + Vasopressin Moderate
- Foscarnet + Vasopressin Moderate
- Haloperidol + Vasopressin Moderate
- Ibuprofen + Vasopressin Moderate
Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Frequently asked questions
Can I take Indomethacin with Vasopressin?
MediHelp rates the interaction as moderate. Indomethacin and Vasopressin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indomethacin may prolong and intensify the hemodynamic effects of vasopressin, including its effects on cardiac index and systemic vascular resistance. This can lead to a stronger or longer pressor response than expected.
How serious is the interaction between Indomethacin and Vasopressin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and hemodynamic parameters closely and titrate the vasopressin infusion to the desired response. Reduce the dose if an excessive pressor effect occurs.
What other medicines interact with Vasopressin?
MediHelp also lists interactions of Vasopressin with, for example, Carbamazepine, Clomipramine, Clozapine. The full list is on the Vasopressin page.
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