Drug interactions
Cobicistat + Progesterone
Severity: Moderate
Cobicistat and Progesterone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat strongly inhibits CYP3A4, which metabolizes progesterone, and may increase progesterone exposure. This could cause more progestogenic adverse effects.
What this interaction means in plain words
Cobicistat and Progesterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cobicistat belongs to Miscellaneous; Progesterone belongs to Endocrine.
Why it happens
CYP3A4 inhibition by cobicistat reduces progesterone clearance.
What to do
Monitor for progestogenic adverse effects and consider a lower progesterone dose. For contraception, use a method not affected by this interaction.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Progesterone
Other interactions of Cobicistat
- Alfuzosin + Cobicistat Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Cobicistat + Colchicine Contraindicated
- Cobicistat + Dronedarone Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Cobicistat + Eplerenone Contraindicated
Frequently asked questions
Can I take Cobicistat with Progesterone?
MediHelp rates the interaction as moderate. Cobicistat and Progesterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cobicistat strongly inhibits CYP3A4, which metabolizes progesterone, and may increase progesterone exposure. This could cause more progestogenic adverse effects.
How serious is the interaction between Cobicistat and Progesterone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for progestogenic adverse effects and consider a lower progesterone dose. For contraception, use a method not affected by this interaction.
What other medicines interact with Progesterone?
MediHelp also lists interactions of Progesterone with, for example, Apalutamide, Carbamazepine, Enzalutamide. The full list is on the Progesterone page.
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