Drug interactions
Cobicistat + Vilazodone
Severity: Moderate
Cobicistat and Vilazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat is a potent CYP3A inhibitor used as a pharmacokinetic booster and can substantially increase vilazodone levels. This raises the risk of dose-related adverse effects including serotonin toxicity.
What this interaction means in plain words
Cobicistat and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cobicistat belongs to Miscellaneous; Vilazodone belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4-mediated metabolism of vilazodone.
What to do
Limit vilazodone to 20 mg daily while cobicistat is used and monitor for adverse effects. Return to the usual dose after cobicistat is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Other interactions of Cobicistat
- Alfuzosin + Cobicistat Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Cobicistat + Colchicine Contraindicated
- Cobicistat + Dronedarone Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Cobicistat + Eplerenone Contraindicated
Frequently asked questions
Can I take Cobicistat with Vilazodone?
MediHelp rates the interaction as moderate. Cobicistat and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cobicistat is a potent CYP3A inhibitor used as a pharmacokinetic booster and can substantially increase vilazodone levels. This raises the risk of dose-related adverse effects including serotonin toxicity.
How serious is the interaction between Cobicistat and Vilazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit vilazodone to 20 mg daily while cobicistat is used and monitor for adverse effects. Return to the usual dose after cobicistat is stopped.
What other medicines interact with Vilazodone?
MediHelp also lists interactions of Vilazodone with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Vilazodone page.
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