Drug interactions
Codeine + Givosiran
Severity: Moderate
Codeine and Givosiran: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givosiran can moderately inhibit CYP2D6, which activates codeine to morphine. Analgesia may be reduced and codeine exposure may rise.
What this interaction means in plain words
Codeine and Givosiran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Codeine belongs to Musculoskeletal; Givosiran belongs to Miscellaneous.
Why it happens
Givosiran-related reduction in CYP2D6 activity, decreasing conversion of codeine to morphine.
What to do
Monitor pain control and consider an analgesic not reliant on CYP2D6 activation. Watch for sedation from parent codeine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Codeine
- Alvimopan + Codeine Contraindicated
- Codeine + Isocarboxazid Contraindicated
- Codeine + Olanzapine / samidorphan Contraindicated
- Codeine + Phenelzine Contraindicated
- Codeine + Tranylcypromine Contraindicated
- Alfentanil + Codeine Major
Other interactions of Givosiran
- Duloxetine + Givosiran Major
- Givosiran + Pimozide Major
- Givosiran + Propafenone Major
- Givosiran + Theophylline Major
- Givosiran + Thioridazine Major
- Givosiran + Tizanidine Major
Frequently asked questions
Can I take Codeine with Givosiran?
MediHelp rates the interaction as moderate. Codeine and Givosiran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Givosiran can moderately inhibit CYP2D6, which activates codeine to morphine. Analgesia may be reduced and codeine exposure may rise.
How serious is the interaction between Codeine and Givosiran?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor pain control and consider an analgesic not reliant on CYP2D6 activation. Watch for sedation from parent codeine.
What other medicines interact with Codeine?
MediHelp also lists interactions of Codeine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Codeine page.
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