Drug interactions
Colchicine + Darunavir
Severity: Major
Colchicine and Darunavir: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darunavir, usually given with ritonavir or cobicistat, inhibits CYP3A4 and increases colchicine concentrations. This can lead to life-threatening colchicine toxicity, especially in patients with kidney or liver disease.
What this interaction means in plain words
Colchicine and Darunavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Colchicine belongs to Genitourinary; Darunavir belongs to Anti Virals.
Why it happens
Boosted darunavir inhibits CYP3A4 (and P-gp), reducing colchicine clearance.
What to do
Avoid in renal or hepatic impairment. Otherwise reduce the colchicine dose or frequency per labeling and monitor for gastrointestinal, neuromuscular and hematologic toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Colchicine
- Clarithromycin + Colchicine Contraindicated
- Cobicistat + Colchicine Contraindicated
- Colchicine + Cyclosporine Contraindicated
- Colchicine + Ensitrelvir Contraindicated
- Colchicine + Levoketoconazole Contraindicated
- Colchicine + Nirmatrelvir Contraindicated
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Colchicine with Darunavir?
MediHelp rates the interaction as major. Colchicine and Darunavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Darunavir, usually given with ritonavir or cobicistat, inhibits CYP3A4 and increases colchicine concentrations. This can lead to life-threatening colchicine toxicity, especially in patients with kidney or liver disease.
How serious is the interaction between Colchicine and Darunavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in renal or hepatic impairment. Otherwise reduce the colchicine dose or frequency per labeling and monitor for gastrointestinal, neuromuscular and hematologic toxicity.
What other medicines interact with Colchicine?
MediHelp also lists interactions of Colchicine with, for example, Clarithromycin, Cobicistat, Cyclosporine. The full list is on the Colchicine page.
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