Drug interactions
Colchicine + Eliglustat
Severity: Major
Colchicine and Eliglustat: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eliglustat inhibits P-glycoprotein and may increase colchicine concentrations. Raised colchicine exposure increases the risk of serious toxicity, particularly with renal or hepatic impairment.
What this interaction means in plain words
Colchicine and Eliglustat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Colchicine belongs to Genitourinary; Eliglustat belongs to Miscellaneous.
Why it happens
Eliglustat inhibits P-gp-mediated efflux of colchicine, raising its systemic exposure.
What to do
Avoid in patients with renal or hepatic impairment. Otherwise reduce the colchicine dose per labeling and monitor for signs of toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Colchicine
- Clarithromycin + Colchicine Contraindicated
- Cobicistat + Colchicine Contraindicated
- Colchicine + Cyclosporine Contraindicated
- Colchicine + Ensitrelvir Contraindicated
- Colchicine + Levoketoconazole Contraindicated
- Colchicine + Nirmatrelvir Contraindicated
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Colchicine with Eliglustat?
MediHelp rates the interaction as major. Colchicine and Eliglustat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Eliglustat inhibits P-glycoprotein and may increase colchicine concentrations. Raised colchicine exposure increases the risk of serious toxicity, particularly with renal or hepatic impairment.
How serious is the interaction between Colchicine and Eliglustat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in patients with renal or hepatic impairment. Otherwise reduce the colchicine dose per labeling and monitor for signs of toxicity.
What other medicines interact with Colchicine?
MediHelp also lists interactions of Colchicine with, for example, Clarithromycin, Cobicistat, Cyclosporine. The full list is on the Colchicine page.
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