Drug interactions
Colchicine + Fosaprepitant
Severity: Moderate
Colchicine and Fosaprepitant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosaprepitant, via aprepitant, is a moderate CYP3A4 inhibitor and may modestly raise colchicine levels after a single intravenous dose. The effect is usually transient and limited, but colchicine toxicity is a concern in vulnerable patients.
What this interaction means in plain words
Colchicine and Fosaprepitant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Colchicine belongs to Genitourinary; Fosaprepitant belongs to Gastrointestinal Tract.
Why it happens
Aprepitant weakly to moderately inhibits CYP3A4, reducing colchicine metabolism.
What to do
Monitor for colchicine toxicity such as diarrhea, myalgia and cytopenias, particularly in renal or hepatic impairment. Consider temporarily lowering the colchicine dose if the patient is high risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Colchicine and Fosaprepitant, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Colchicine
- Clarithromycin + Colchicine Contraindicated
- Cobicistat + Colchicine Contraindicated
- Colchicine + Cyclosporine Contraindicated
- Colchicine + Ensitrelvir Contraindicated
- Colchicine + Levoketoconazole Contraindicated
- Colchicine + Nirmatrelvir Contraindicated
Other interactions of Fosaprepitant
- Flibanserin + Fosaprepitant Contraindicated
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amiodarone + Fosaprepitant Moderate
- Amobarbital + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
Frequently asked questions
Can I take Colchicine with Fosaprepitant?
MediHelp rates the interaction as moderate. Colchicine and Fosaprepitant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fosaprepitant, via aprepitant, is a moderate CYP3A4 inhibitor and may modestly raise colchicine levels after a single intravenous dose. The effect is usually transient and limited, but colchicine toxicity is a concern in vulnerable patients.
How serious is the interaction between Colchicine and Fosaprepitant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for colchicine toxicity such as diarrhea, myalgia and cytopenias, particularly in renal or hepatic impairment. Consider temporarily lowering the colchicine dose if the patient is high risk.
What other medicines interact with Colchicine?
MediHelp also lists interactions of Colchicine with, for example, Clarithromycin, Cobicistat, Cyclosporine. The full list is on the Colchicine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
