Drug interactions
Colchicine + Lasmiditan
Severity: Moderate
Colchicine and Lasmiditan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan inhibits P-glycoprotein in vitro and may raise concentrations of P-gp substrates such as colchicine. The clinical impact is uncertain but toxicity is possible given colchicine's narrow therapeutic index.
What this interaction means in plain words
Colchicine and Lasmiditan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Colchicine belongs to Genitourinary; Lasmiditan belongs to Central Nervous System.
Why it happens
P-gp inhibition by lasmiditan may reduce colchicine efflux.
What to do
Monitor for colchicine toxicity such as diarrhea, nausea or muscle weakness, and consider a lower colchicine dose, especially in renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Colchicine
- Clarithromycin + Colchicine Contraindicated
- Cobicistat + Colchicine Contraindicated
- Colchicine + Cyclosporine Contraindicated
- Colchicine + Ensitrelvir Contraindicated
- Colchicine + Levoketoconazole Contraindicated
- Colchicine + Nirmatrelvir Contraindicated
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Colchicine with Lasmiditan?
MediHelp rates the interaction as moderate. Colchicine and Lasmiditan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lasmiditan inhibits P-glycoprotein in vitro and may raise concentrations of P-gp substrates such as colchicine. The clinical impact is uncertain but toxicity is possible given colchicine's narrow therapeutic index.
How serious is the interaction between Colchicine and Lasmiditan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for colchicine toxicity such as diarrhea, nausea or muscle weakness, and consider a lower colchicine dose, especially in renal impairment.
What other medicines interact with Colchicine?
MediHelp also lists interactions of Colchicine with, for example, Clarithromycin, Cobicistat, Cyclosporine. The full list is on the Colchicine page.
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