Drug interactions
Colchicine + Vemurafenib
Severity: Major
Colchicine and Vemurafenib: major interaction.
Last updated Sources: EMA SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vemurafenib may inhibit P-glycoprotein and raise colchicine concentrations. Increased colchicine exposure can cause serious or fatal toxicity, particularly in patients with renal or hepatic impairment.
What this interaction means in plain words
Colchicine and Vemurafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Colchicine belongs to Genitourinary; Vemurafenib belongs to Oncology.
Why it happens
Vemurafenib is a P-glycoprotein inhibitor that may decrease colchicine efflux and clearance.
What to do
Avoid the combination where possible; if needed, reduce the colchicine dose per labeling and monitor for GI, neuromuscular and hematologic toxicity. Do not use in renal or hepatic impairment.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Colchicine
- Clarithromycin + Colchicine Contraindicated
- Cobicistat + Colchicine Contraindicated
- Colchicine + Cyclosporine Contraindicated
- Colchicine + Ensitrelvir Contraindicated
- Colchicine + Levoketoconazole Contraindicated
- Colchicine + Nirmatrelvir Contraindicated
Other interactions of Vemurafenib
Frequently asked questions
Can I take Colchicine with Vemurafenib?
MediHelp rates the interaction as major. Colchicine and Vemurafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vemurafenib may inhibit P-glycoprotein and raise colchicine concentrations. Increased colchicine exposure can cause serious or fatal toxicity, particularly in patients with renal or hepatic impairment.
How serious is the interaction between Colchicine and Vemurafenib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if needed, reduce the colchicine dose per labeling and monitor for GI, neuromuscular and hematologic toxicity. Do not use in renal or hepatic impairment.
What other medicines interact with Colchicine?
MediHelp also lists interactions of Colchicine with, for example, Clarithromycin, Cobicistat, Cyclosporine. The full list is on the Colchicine page.
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