Drug interactions
Colesevelam + Dapagliflozin-metformin
Severity: Minor
Colesevelam and Dapagliflozin-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Colesevelam may bind metformin in the gut and reduce its absorption in some settings, although colesevelam itself also lowers glucose. The net clinical effect is usually small, but timing may matter.
What this interaction means in plain words
Colesevelam and Dapagliflozin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Colesevelam belongs to Endocrine; Dapagliflozin-metformin belongs to Endocrine.
Why it happens
Bile acid sequestrant binding in the gastrointestinal tract may reduce metformin absorption; evidence is limited.
What to do
Give metformin at least 4 hours before colesevelam if feasible, and monitor glycemic control.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Colesevelam and Dapagliflozin-metformin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Dapagliflozin-metformin
Other interactions of Colesevelam
- Amlodipine-olmesartan-hydrochlorothiazide + Colesevelam Moderate
- Amlodipine-olmesartan + Colesevelam Moderate
- Chenodiol + Colesevelam Moderate
- Cholic acid + Colesevelam Moderate
- Colesevelam + Cyclosporin Moderate
- Colesevelam + Glibenclamide Moderate
Frequently asked questions
Can I take Colesevelam with Dapagliflozin-metformin?
MediHelp rates the interaction as minor. Colesevelam and Dapagliflozin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Colesevelam may bind metformin in the gut and reduce its absorption in some settings, although colesevelam itself also lowers glucose. The net clinical effect is usually small, but timing may matter.
How serious is the interaction between Colesevelam and Dapagliflozin-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give metformin at least 4 hours before colesevelam if feasible, and monitor glycemic control.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
