Drug interactions
Colesevelam + Sarecycline
Severity: Minor
Colesevelam and Sarecycline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Colesevelam may bind oral sarecycline in the gut and lower its absorption. This could reduce efficacy in acne treatment.
What this interaction means in plain words
Colesevelam and Sarecycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Colesevelam belongs to Endocrine; Sarecycline belongs to Anti Bacterial.
Why it happens
Resin binding in the gastrointestinal tract decreases sarecycline absorption.
What to do
Separate administration by at least 2 hours, giving sarecycline first, and monitor acne response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Colesevelam
- Amlodipine-olmesartan-hydrochlorothiazide + Colesevelam Moderate
- Amlodipine-olmesartan + Colesevelam Moderate
- Chenodiol + Colesevelam Moderate
- Cholic acid + Colesevelam Moderate
- Colesevelam + Cyclosporin Moderate
- Colesevelam + Glibenclamide Moderate
Other interactions of Sarecycline
- Acitretin + Sarecycline Contraindicated
- Isotretinoin + Sarecycline Major
- Sarecycline + Tretinoin Major
- Aluminum hydroxide + Sarecycline Moderate
- Calcium carbonate + Sarecycline Moderate
- Calcium + Sarecycline Moderate
Frequently asked questions
Can I take Colesevelam with Sarecycline?
MediHelp rates the interaction as minor. Colesevelam and Sarecycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Colesevelam may bind oral sarecycline in the gut and lower its absorption. This could reduce efficacy in acne treatment.
How serious is the interaction between Colesevelam and Sarecycline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate administration by at least 2 hours, giving sarecycline first, and monitor acne response.
What other medicines interact with Colesevelam?
MediHelp also lists interactions of Colesevelam with, for example, Amlodipine-olmesartan-hydrochlorothiazide, Amlodipine-olmesartan, Chenodiol. The full list is on the Colesevelam page.
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