Drug interactions
Colesevelam + Saxagliptin-metformin
Severity: Minor
Colesevelam and Saxagliptin-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Colesevelam may reduce absorption of metformin when taken at the same time, and it also lowers glucose by itself. Effects on saxagliptin are not significant.
What this interaction means in plain words
Colesevelam and Saxagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Colesevelam belongs to Endocrine; Saxagliptin-metformin belongs to Endocrine.
Why it happens
Bile acid sequestrant binding in the gut may reduce metformin absorption; colesevelam also independently lowers glucose.
What to do
Give metformin at least 4 hours before colesevelam if possible. Monitor glycemic control after starting or stopping colesevelam.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Saxagliptin-metformin
Other interactions of Colesevelam
- Amlodipine-olmesartan-hydrochlorothiazide + Colesevelam Moderate
- Amlodipine-olmesartan + Colesevelam Moderate
- Chenodiol + Colesevelam Moderate
- Cholic acid + Colesevelam Moderate
- Colesevelam + Cyclosporin Moderate
- Colesevelam + Glibenclamide Moderate
Frequently asked questions
Can I take Colesevelam with Saxagliptin-metformin?
MediHelp rates the interaction as minor. Colesevelam and Saxagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Colesevelam may reduce absorption of metformin when taken at the same time, and it also lowers glucose by itself. Effects on saxagliptin are not significant.
How serious is the interaction between Colesevelam and Saxagliptin-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give metformin at least 4 hours before colesevelam if possible. Monitor glycemic control after starting or stopping colesevelam.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
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