Drug interactions
Colesevelam + Verapamil
Severity: Minor
Colesevelam and Verapamil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bile acid sequestrants can bind oral drugs in the gut and lessen their absorption. Reduced verapamil exposure could weaken blood pressure or rate control, particularly with sustained-release products.
What this interaction means in plain words
Colesevelam and Verapamil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Colesevelam belongs to Endocrine; Verapamil belongs to Cardiovascular.
Why it happens
Binding of verapamil in the gastrointestinal tract by colesevelam, reducing absorption.
What to do
Give verapamil at least 4 hours before colesevelam and monitor blood pressure and heart rate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Colesevelam
- Amlodipine-olmesartan-hydrochlorothiazide + Colesevelam Moderate
- Amlodipine-olmesartan + Colesevelam Moderate
- Chenodiol + Colesevelam Moderate
- Cholic acid + Colesevelam Moderate
- Colesevelam + Cyclosporin Moderate
- Colesevelam + Glibenclamide Moderate
Frequently asked questions
Can I take Colesevelam with Verapamil?
MediHelp rates the interaction as minor. Colesevelam and Verapamil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bile acid sequestrants can bind oral drugs in the gut and lessen their absorption. Reduced verapamil exposure could weaken blood pressure or rate control, particularly with sustained-release products.
How serious is the interaction between Colesevelam and Verapamil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give verapamil at least 4 hours before colesevelam and monitor blood pressure and heart rate.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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