Drug interactions
Colesevelam + Warfarin
Severity: Minor
Colesevelam and Warfarin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Colesevelam has little effect on warfarin in studies, unlike older bile acid resins such as cholestyramine. A clinically relevant interaction is unlikely, though separating doses is a reasonable precaution.
What this interaction means in plain words
Colesevelam and Warfarin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Colesevelam belongs to Endocrine; Warfarin belongs to Cardiovascular.
Why it happens
Possible minor binding of warfarin in the gut, but no significant absorption effect has been shown.
What to do
Routine INR monitoring is sufficient. Consider giving warfarin at least 4 hours before colesevelam if INR instability occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Other interactions of Colesevelam
- Amlodipine-olmesartan-hydrochlorothiazide + Colesevelam Moderate
- Amlodipine-olmesartan + Colesevelam Moderate
- Chenodiol + Colesevelam Moderate
- Cholic acid + Colesevelam Moderate
- Colesevelam + Cyclosporin Moderate
- Colesevelam + Glibenclamide Moderate
Frequently asked questions
Can I take Colesevelam with Warfarin?
MediHelp rates the interaction as minor. Colesevelam and Warfarin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Colesevelam has little effect on warfarin in studies, unlike older bile acid resins such as cholestyramine. A clinically relevant interaction is unlikely, though separating doses is a reasonable precaution.
How serious is the interaction between Colesevelam and Warfarin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Routine INR monitoring is sufficient. Consider giving warfarin at least 4 hours before colesevelam if INR instability occurs.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
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