Drug interactions
Corticotropin + Hydrochlorothiazide-irbesartan
Severity: Moderate
Corticotropin and Hydrochlorothiazide-irbesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticotropin stimulates adrenal steroid release and can cause potassium loss and fluid retention, adding to thiazide-induced hypokalemia. This can matter during prolonged or high-dose courses.
What this interaction means in plain words
Corticotropin and Hydrochlorothiazide-irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Corticotropin belongs to Endocrine; Hydrochlorothiazide-irbesartan belongs to Cardiovascular.
Why it happens
Corticotropin-induced mineralocorticoid and glucocorticoid excess increases renal potassium excretion in addition to thiazide kaliuresis.
What to do
Monitor serum potassium and blood pressure during corticotropin therapy and supplement potassium if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Other interactions of Corticotropin
Frequently asked questions
Can I take Corticotropin with Hydrochlorothiazide-irbesartan?
MediHelp rates the interaction as moderate. Corticotropin and Hydrochlorothiazide-irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticotropin stimulates adrenal steroid release and can cause potassium loss and fluid retention, adding to thiazide-induced hypokalemia. This can matter during prolonged or high-dose courses.
How serious is the interaction between Corticotropin and Hydrochlorothiazide-irbesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and blood pressure during corticotropin therapy and supplement potassium if needed.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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