Drug interactions
Corticotropin + Insulin degludec-insulin aspart
Severity: Moderate
Corticotropin and Insulin degludec-insulin aspart: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticotropin stimulates cortisol release, which raises blood glucose and opposes insulin. Higher insulin doses may be needed during treatment.
What this interaction means in plain words
Corticotropin and Insulin degludec-insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Corticotropin belongs to Endocrine; Insulin degludec-insulin aspart belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism: induced glucocorticoid excess increases gluconeogenesis and insulin resistance.
What to do
Monitor glucose more frequently during corticotropin therapy and increase insulin as needed. Reduce insulin when therapy ends.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-insulin aspart
- Chlorpropamide + Insulin degludec-insulin aspart Major
- Clozapine + Insulin degludec-insulin aspart Major
- Diazoxide + Insulin degludec-insulin aspart Major
- Ethanol + Insulin degludec-insulin aspart Major
- Insulin degludec-insulin aspart + Mecasermin Major
- Insulin degludec-insulin aspart + Pioglitazone Major
Other interactions of Corticotropin
Frequently asked questions
Can I take Corticotropin with Insulin degludec-insulin aspart?
MediHelp rates the interaction as moderate. Corticotropin and Insulin degludec-insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticotropin stimulates cortisol release, which raises blood glucose and opposes insulin. Higher insulin doses may be needed during treatment.
How serious is the interaction between Corticotropin and Insulin degludec-insulin aspart?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose more frequently during corticotropin therapy and increase insulin as needed. Reduce insulin when therapy ends.
What other medicines interact with Insulin degludec-insulin aspart?
MediHelp also lists interactions of Insulin degludec-insulin aspart with, for example, Chlorpropamide, Clozapine, Diazoxide. The full list is on the Insulin degludec-insulin aspart page.
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