Drug interactions
Corticotropin + Metolazone
Severity: Moderate
Corticotropin and Metolazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticotropin stimulates adrenal steroid release with mineralocorticoid effects that promote potassium loss. Combined with metolazone, which also wastes potassium, hypokalemia can be enhanced.
What this interaction means in plain words
Corticotropin and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Corticotropin belongs to Endocrine; Metolazone belongs to Cardiovascular.
Why it happens
Additive potassium-wasting effects: adrenal mineralocorticoid stimulation plus thiazide-type distal tubular diuresis.
What to do
Monitor serum potassium and magnesium regularly and supplement as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metolazone
Other interactions of Corticotropin
Frequently asked questions
Can I take Corticotropin with Metolazone?
MediHelp rates the interaction as moderate. Corticotropin and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticotropin stimulates adrenal steroid release with mineralocorticoid effects that promote potassium loss. Combined with metolazone, which also wastes potassium, hypokalemia can be enhanced.
How serious is the interaction between Corticotropin and Metolazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium regularly and supplement as needed.
What other medicines interact with Metolazone?
MediHelp also lists interactions of Metolazone with, for example, Amifostine, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide. The full list is on the Metolazone page.
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