Drug interactions
Crizotinib + Crofelemer
Severity: Minor
Crizotinib and Crofelemer: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crofelemer may inhibit CYP3A4 in the gut, but it is minimally absorbed, so a meaningful rise in crizotinib levels is unlikely. Any effect would be limited to intestinal first-pass metabolism.
What this interaction means in plain words
Crizotinib and Crofelemer have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Crizotinib belongs to Oncology; Crofelemer belongs to Gastrointestinal Tract.
Why it happens
Possible intestinal CYP3A4 inhibition by crofelemer, with minimal systemic absorption.
What to do
No routine adjustment is needed. Monitor for crizotinib adverse effects if they emerge after crofelemer is started.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Other interactions of Crofelemer
- Crofelemer + Ergotamine Moderate
- Alfuzosin + Crofelemer Minor
- Amiodarone + Crofelemer Minor
- Apixaban + Crofelemer Minor
- Aprepitant + Crofelemer Minor
- Armodafinil + Crofelemer Minor
Frequently asked questions
Can I take Crizotinib with Crofelemer?
MediHelp rates the interaction as minor. Crizotinib and Crofelemer have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Crofelemer may inhibit CYP3A4 in the gut, but it is minimally absorbed, so a meaningful rise in crizotinib levels is unlikely. Any effect would be limited to intestinal first-pass metabolism.
How serious is the interaction between Crizotinib and Crofelemer?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor for crizotinib adverse effects if they emerge after crofelemer is started.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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