Drug interactions
Crizotinib + Digoxin
Severity: Moderate
Crizotinib and Digoxin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib inhibits P-glycoprotein and may raise digoxin concentrations. Digoxin has a narrow therapeutic index, so increased exposure may cause toxicity such as arrhythmias, nausea and visual disturbance. Crizotinib can also cause bradycardia, which compounds the risk.
What this interaction means in plain words
Crizotinib and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Crizotinib belongs to Oncology; Digoxin belongs to Cardiovascular.
Why it happens
Inhibition of intestinal and renal P-glycoprotein efflux of digoxin, with additive bradycardic effects.
What to do
Monitor serum digoxin concentrations, heart rate and ECG, and reduce the digoxin dose if levels rise or toxicity signs appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Crizotinib with Digoxin?
MediHelp rates the interaction as moderate. Crizotinib and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crizotinib inhibits P-glycoprotein and may raise digoxin concentrations. Digoxin has a narrow therapeutic index, so increased exposure may cause toxicity such as arrhythmias, nausea and visual disturbance. Crizotinib can also cause bradycardia, which compounds the risk.
How serious is the interaction between Crizotinib and Digoxin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum digoxin concentrations, heart rate and ECG, and reduce the digoxin dose if levels rise or toxicity signs appear.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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