Drug interactions
Crizotinib + Dihydroergotamine
Severity: Major
Crizotinib and Dihydroergotamine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib inhibits CYP3A4 and may raise dihydroergotamine levels. Excess dihydroergotamine can cause peripheral and cerebral ischemia (ergotism), a serious and sometimes irreversible toxicity.
What this interaction means in plain words
Crizotinib and Dihydroergotamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Crizotinib belongs to Oncology; Dihydroergotamine belongs to Central Nervous System.
Why it happens
Crizotinib inhibits CYP3A4-mediated metabolism of dihydroergotamine.
What to do
Avoid the combination and use a non-ergot migraine therapy. If used, monitor closely for vasospasm, numbness, cold extremities or ischemia.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Other interactions of Dihydroergotamine
- Almotriptan + Dihydroergotamine Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
- Dihydroergotamine + Dopamine Contraindicated
- Dihydroergotamine + Dronedarone Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Dihydroergotamine + Eletriptan Contraindicated
Frequently asked questions
Can I take Crizotinib with Dihydroergotamine?
MediHelp rates the interaction as major. Crizotinib and Dihydroergotamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Crizotinib inhibits CYP3A4 and may raise dihydroergotamine levels. Excess dihydroergotamine can cause peripheral and cerebral ischemia (ergotism), a serious and sometimes irreversible toxicity.
How serious is the interaction between Crizotinib and Dihydroergotamine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-ergot migraine therapy. If used, monitor closely for vasospasm, numbness, cold extremities or ischemia.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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