Drug interactions
Crizotinib + Eletriptan
Severity: Moderate
Crizotinib and Eletriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib is a moderate CYP3A4 inhibitor and can raise eletriptan exposure, since eletriptan is extensively metabolized by CYP3A4. Higher levels may increase triptan adverse effects such as hypertension and chest symptoms.
What this interaction means in plain words
Crizotinib and Eletriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Crizotinib belongs to Oncology; Eletriptan belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4-mediated metabolism of eletriptan by crizotinib.
What to do
Use the lowest effective eletriptan dose and monitor blood pressure and triptan adverse effects. Consider a triptan not dependent on CYP3A4 such as sumatriptan or naratriptan.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Crizotinib and Eletriptan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Crizotinib with Eletriptan?
MediHelp rates the interaction as moderate. Crizotinib and Eletriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crizotinib is a moderate CYP3A4 inhibitor and can raise eletriptan exposure, since eletriptan is extensively metabolized by CYP3A4. Higher levels may increase triptan adverse effects such as hypertension and chest symptoms.
How serious is the interaction between Crizotinib and Eletriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective eletriptan dose and monitor blood pressure and triptan adverse effects. Consider a triptan not dependent on CYP3A4 such as sumatriptan or naratriptan.
What other medicines interact with Eletriptan?
MediHelp also lists interactions of Eletriptan with, for example, Almotriptan, Atazanavir, Ceritinib. The full list is on the Eletriptan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
