Drug interactions
Crizotinib + Everolimus
Severity: Moderate
Crizotinib and Everolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib inhibits P-glycoprotein and CYP3A and may raise everolimus concentrations. Higher exposure may increase stomatitis, infection, pneumonitis and metabolic adverse effects.
What this interaction means in plain words
Crizotinib and Everolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Crizotinib belongs to Oncology; Everolimus belongs to Oncology.
Why it happens
Crizotinib inhibits P-gp efflux and CYP3A4 metabolism of everolimus.
What to do
Monitor for everolimus toxicity and consider checking everolimus trough levels. Reduce the everolimus dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Crizotinib with Everolimus?
MediHelp rates the interaction as moderate. Crizotinib and Everolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crizotinib inhibits P-glycoprotein and CYP3A and may raise everolimus concentrations. Higher exposure may increase stomatitis, infection, pneumonitis and metabolic adverse effects.
How serious is the interaction between Crizotinib and Everolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for everolimus toxicity and consider checking everolimus trough levels. Reduce the everolimus dose if adverse effects occur.
What other medicines interact with Everolimus?
MediHelp also lists interactions of Everolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Levoketoconazole. The full list is on the Everolimus page.
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