Drug interactions
Crizotinib + Fedratinib
Severity: Moderate
Crizotinib and Fedratinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib is a moderate CYP3A4 inhibitor and may increase crizotinib exposure. Crizotinib may also raise fedratinib levels through CYP3A4 inhibition. This may heighten toxicities, including hepatotoxicity, QT prolongation and gastrointestinal effects.
What this interaction means in plain words
Crizotinib and Fedratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Crizotinib belongs to Oncology; Fedratinib belongs to Oncology.
Why it happens
Fedratinib inhibits CYP3A4, reducing crizotinib clearance.
What to do
Monitor ECG, liver tests and gastrointestinal tolerance. Reduce the dose of either drug if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Crizotinib with Fedratinib?
MediHelp rates the interaction as moderate. Crizotinib and Fedratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib is a moderate CYP3A4 inhibitor and may increase crizotinib exposure. Crizotinib may also raise fedratinib levels through CYP3A4 inhibition. This may heighten toxicities, including hepatotoxicity, QT prolongation and gastrointestinal effects.
How serious is the interaction between Crizotinib and Fedratinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG, liver tests and gastrointestinal tolerance. Reduce the dose of either drug if toxicity appears.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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