Drug interactions
Crizotinib + Gepirone
Severity: Major
Crizotinib and Gepirone: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib raises gepirone exposure through CYP3A4 inhibition, and both drugs prolong QTc. Together they increase the risk of arrhythmia.
What this interaction means in plain words
Crizotinib and Gepirone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Crizotinib belongs to Oncology; Gepirone belongs to Central Nervous System.
Why it happens
CYP3A4 inhibition raises gepirone levels, plus additive QT prolongation.
What to do
Halve the gepirone dose with a moderate CYP3A4 inhibitor and monitor ECG and electrolytes. Avoid if baseline QTc is prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Other interactions of Gepirone
- Clarithromycin + Gepirone Contraindicated
- Gepirone + Isocarboxazid Contraindicated
- Gepirone + Itraconazole Contraindicated
- Gepirone + Ketoconazole Contraindicated
- Gepirone + Linezolid Contraindicated
- Gepirone + Phenelzine Contraindicated
Frequently asked questions
Can I take Crizotinib with Gepirone?
MediHelp rates the interaction as major. Crizotinib and Gepirone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Crizotinib raises gepirone exposure through CYP3A4 inhibition, and both drugs prolong QTc. Together they increase the risk of arrhythmia.
How serious is the interaction between Crizotinib and Gepirone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Halve the gepirone dose with a moderate CYP3A4 inhibitor and monitor ECG and electrolytes. Avoid if baseline QTc is prolonged.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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