Drug interactions
Crizotinib + Goserelin
Severity: Moderate
Crizotinib and Goserelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib can prolong the QT interval and cause bradycardia, and androgen deprivation with goserelin may add to the QT effect. The combination may increase the risk of torsades de pointes.
What this interaction means in plain words
Crizotinib and Goserelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Crizotinib belongs to Oncology; Goserelin belongs to Endocrine.
Why it happens
Additive QT prolongation from crizotinib and testosterone suppression by goserelin.
What to do
Obtain a baseline ECG and electrolytes and repeat periodically, correcting potassium and magnesium. Reduce the crizotinib dose or stop it if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Goserelin
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Crizotinib with Goserelin?
MediHelp rates the interaction as moderate. Crizotinib and Goserelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crizotinib can prolong the QT interval and cause bradycardia, and androgen deprivation with goserelin may add to the QT effect. The combination may increase the risk of torsades de pointes.
How serious is the interaction between Crizotinib and Goserelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and electrolytes and repeat periodically, correcting potassium and magnesium. Reduce the crizotinib dose or stop it if QTc becomes markedly prolonged.
What other medicines interact with Goserelin?
MediHelp also lists interactions of Goserelin with, for example, Amisulpride, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Goserelin page.
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