Drug interactions
Crizotinib + Indacaterol
Severity: Major
Crizotinib and Indacaterol: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib can prolong QT and cause bradycardia, and indacaterol may add arrhythmic risk through QT effects, tachycardia and hypokalemia. The combination may raise the risk of serious ventricular arrhythmia.
What this interaction means in plain words
Crizotinib and Indacaterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Crizotinib belongs to Oncology; Indacaterol belongs to Respiratory.
Why it happens
Additive QT prolongation with beta-agonist-induced hypokalemia.
What to do
Monitor ECG and electrolytes periodically and correct abnormalities. Consider an alternative bronchodilator if QTc lengthens significantly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Indacaterol
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Crizotinib with Indacaterol?
MediHelp rates the interaction as major. Crizotinib and Indacaterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Crizotinib can prolong QT and cause bradycardia, and indacaterol may add arrhythmic risk through QT effects, tachycardia and hypokalemia. The combination may raise the risk of serious ventricular arrhythmia.
How serious is the interaction between Crizotinib and Indacaterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes periodically and correct abnormalities. Consider an alternative bronchodilator if QTc lengthens significantly.
What other medicines interact with Indacaterol?
MediHelp also lists interactions of Indacaterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Indacaterol page.
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