Drug interactions
Crizotinib + Lopinavir
Severity: Major
Crizotinib and Lopinavir: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and lopinavir/ritonavir also inhibits CYP3A4, which can raise crizotinib concentrations. Together these effects increase the risk of torsade de pointes and bradycardia.
What this interaction means in plain words
Crizotinib and Lopinavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Crizotinib belongs to Oncology; Lopinavir belongs to Anti Virals.
Why it happens
Additive QT prolongation plus CYP3A4 inhibition by ritonavir-boosted lopinavir increasing crizotinib exposure.
What to do
Avoid the combination if possible, as strong CYP3A inhibitors require crizotinib dose reduction. If used, obtain baseline and follow-up ECGs, correct potassium and magnesium, and monitor heart rate.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Crizotinib with Lopinavir?
MediHelp rates the interaction as major. Crizotinib and Lopinavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, and lopinavir/ritonavir also inhibits CYP3A4, which can raise crizotinib concentrations. Together these effects increase the risk of torsade de pointes and bradycardia.
How serious is the interaction between Crizotinib and Lopinavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible, as strong CYP3A inhibitors require crizotinib dose reduction. If used, obtain baseline and follow-up ECGs, correct potassium and magnesium, and monitor heart rate.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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