Drug interactions
Crizotinib + Loratadine
Severity: Minor
Crizotinib and Loratadine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib inhibits CYP3A4 and may raise loratadine concentrations, as loratadine is metabolized partly by CYP3A4. The clinical effect is likely small given loratadine's wide therapeutic index.
What this interaction means in plain words
Crizotinib and Loratadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Crizotinib belongs to Oncology; Loratadine belongs to Respiratory.
Why it happens
Crizotinib inhibition of CYP3A4 (and possibly P-glycoprotein) reduces loratadine clearance.
What to do
No dose change is usually needed; watch for increased sedation or headache.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Loratadine
- Acrivastine + Loratadine Moderate
- Amobarbital + Loratadine Moderate
- Fentanyl + Loratadine Moderate
- Isocarboxazid + Loratadine Moderate
- Levoketoconazole + Loratadine Moderate
- Loratadine + Mavacamten Moderate
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Crizotinib with Loratadine?
MediHelp rates the interaction as minor. Crizotinib and Loratadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Crizotinib inhibits CYP3A4 and may raise loratadine concentrations, as loratadine is metabolized partly by CYP3A4. The clinical effect is likely small given loratadine's wide therapeutic index.
How serious is the interaction between Crizotinib and Loratadine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; watch for increased sedation or headache.
What other medicines interact with Loratadine?
MediHelp also lists interactions of Loratadine with, for example, Acrivastine, Amobarbital, Fentanyl. The full list is on the Loratadine page.
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