Drug interactions
Crizotinib + Midostaurin
Severity: Major
Crizotinib and Midostaurin: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and crizotinib also inhibits CYP3A4, which may increase midostaurin exposure. The combination raises the risk of arrhythmia and midostaurin toxicity.
What this interaction means in plain words
Crizotinib and Midostaurin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Crizotinib belongs to Oncology; Midostaurin belongs to Oncology.
Why it happens
Additive QT prolongation plus CYP3A4 inhibition raising midostaurin levels.
What to do
Avoid if an alternative exists. If used together, monitor ECG, electrolytes and midostaurin adverse effects such as nausea and pulmonary toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Other interactions of Midostaurin
Frequently asked questions
Can I take Crizotinib with Midostaurin?
MediHelp rates the interaction as major. Crizotinib and Midostaurin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, and crizotinib also inhibits CYP3A4, which may increase midostaurin exposure. The combination raises the risk of arrhythmia and midostaurin toxicity.
How serious is the interaction between Crizotinib and Midostaurin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if an alternative exists. If used together, monitor ECG, electrolytes and midostaurin adverse effects such as nausea and pulmonary toxicity.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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