Drug interactions
Crizotinib + Modafinil
Severity: Moderate
Crizotinib and Modafinil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib is a moderate CYP3A inhibitor and may raise concentrations of CYP3A substrates, including modafinil. The increase is expected to be modest and mainly produce more modafinil adverse effects such as headache, nervousness or insomnia.
What this interaction means in plain words
Crizotinib and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Crizotinib belongs to Oncology; Modafinil belongs to Central Nervous System.
Why it happens
Crizotinib inhibits CYP3A4, reducing modafinil clearance.
What to do
Monitor for modafinil adverse effects and reduce the dose if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Modafinil
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Crizotinib with Modafinil?
MediHelp rates the interaction as moderate. Crizotinib and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crizotinib is a moderate CYP3A inhibitor and may raise concentrations of CYP3A substrates, including modafinil. The increase is expected to be modest and mainly produce more modafinil adverse effects such as headache, nervousness or insomnia.
How serious is the interaction between Crizotinib and Modafinil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for modafinil adverse effects and reduce the dose if they occur.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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