Drug interactions
Crizotinib + Omaveloxolone
Severity: Moderate
Crizotinib and Omaveloxolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Omaveloxolone is metabolized by CYP3A4, so crizotinib may increase its exposure. This may increase adverse effects such as liver enzyme elevation and lipid changes.
What this interaction means in plain words
Crizotinib and Omaveloxolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Crizotinib belongs to Oncology; Omaveloxolone belongs to Central Nervous System.
Why it happens
Crizotinib inhibits CYP3A4 metabolism of omaveloxolone.
What to do
Avoid if possible. If necessary, reduce omaveloxolone to 100 mg daily and monitor liver tests and tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Crizotinib and Omaveloxolone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Other interactions of Omaveloxolone
Frequently asked questions
Can I take Crizotinib with Omaveloxolone?
MediHelp rates the interaction as moderate. Crizotinib and Omaveloxolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Omaveloxolone is metabolized by CYP3A4, so crizotinib may increase its exposure. This may increase adverse effects such as liver enzyme elevation and lipid changes.
How serious is the interaction between Crizotinib and Omaveloxolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If necessary, reduce omaveloxolone to 100 mg daily and monitor liver tests and tolerability.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
