Drug interactions
Crizotinib + Palbociclib
Severity: Moderate
Crizotinib and Palbociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Palbociclib is metabolized by CYP3A4, and crizotinib is a moderate CYP3A4 inhibitor, so palbociclib levels may rise. This may increase neutropenia and other adverse effects.
What this interaction means in plain words
Crizotinib and Palbociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Crizotinib belongs to Oncology; Palbociclib belongs to Oncology.
Why it happens
Crizotinib inhibits CYP3A4, decreasing palbociclib clearance.
What to do
Monitor neutrophil counts and consider palbociclib dose reduction if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Other interactions of Palbociclib
Frequently asked questions
Can I take Crizotinib with Palbociclib?
MediHelp rates the interaction as moderate. Crizotinib and Palbociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Palbociclib is metabolized by CYP3A4, and crizotinib is a moderate CYP3A4 inhibitor, so palbociclib levels may rise. This may increase neutropenia and other adverse effects.
How serious is the interaction between Crizotinib and Palbociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neutrophil counts and consider palbociclib dose reduction if toxicity develops.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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