Drug interactions
Crizotinib + Pravastatin
Severity: Minor
Crizotinib and Pravastatin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib may inhibit P-glycoprotein and could increase pravastatin exposure. The effect is expected to be modest, with a small risk of added muscle toxicity.
What this interaction means in plain words
Crizotinib and Pravastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Crizotinib belongs to Oncology; Pravastatin belongs to Cardiovascular.
Why it happens
Possible P-glycoprotein inhibition by crizotinib reducing pravastatin efflux.
What to do
No routine change is needed. Advise patients to report unexplained muscle pain or weakness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pravastatin
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Crizotinib with Pravastatin?
MediHelp rates the interaction as minor. Crizotinib and Pravastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Crizotinib may inhibit P-glycoprotein and could increase pravastatin exposure. The effect is expected to be modest, with a small risk of added muscle toxicity.
How serious is the interaction between Crizotinib and Pravastatin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Advise patients to report unexplained muscle pain or weakness.
What other medicines interact with Pravastatin?
MediHelp also lists interactions of Pravastatin with, for example, Cyclosporin, Gemfibrozil, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Pravastatin page.
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