Drug interactions
Crizotinib + Sevoflurane
Severity: Moderate
Crizotinib and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib can prolong the QT interval and cause bradycardia, and sevoflurane may add to repolarization delay. This combination increases the risk of arrhythmia during anesthesia.
What this interaction means in plain words
Crizotinib and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Crizotinib belongs to Oncology; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic QT prolongation, with crizotinib-related bradycardia as a further contributor.
What to do
Check the baseline ECG and heart rate and correct potassium and magnesium. Monitor the ECG continuously during the procedure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sevoflurane
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Crizotinib with Sevoflurane?
MediHelp rates the interaction as moderate. Crizotinib and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crizotinib can prolong the QT interval and cause bradycardia, and sevoflurane may add to repolarization delay. This combination increases the risk of arrhythmia during anesthesia.
How serious is the interaction between Crizotinib and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check the baseline ECG and heart rate and correct potassium and magnesium. Monitor the ECG continuously during the procedure.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
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