Drug interactions
Crizotinib + Stiripentol
Severity: Moderate
Crizotinib and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits CYP3A4 and P-gp and may also induce CYP3A4, so crizotinib exposure may change unpredictably, most likely increasing.
What this interaction means in plain words
Crizotinib and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Crizotinib belongs to Oncology; Stiripentol belongs to Central Nervous System.
Why it happens
Stiripentol modulates CYP3A4 and P-glycoprotein, altering crizotinib clearance.
What to do
Monitor for crizotinib toxicity (QT, liver enzymes, bradycardia) and loss of efficacy, adjusting dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Other interactions of Stiripentol
Frequently asked questions
Can I take Crizotinib with Stiripentol?
MediHelp rates the interaction as moderate. Crizotinib and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol inhibits CYP3A4 and P-gp and may also induce CYP3A4, so crizotinib exposure may change unpredictably, most likely increasing.
How serious is the interaction between Crizotinib and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for crizotinib toxicity (QT, liver enzymes, bradycardia) and loss of efficacy, adjusting dose as needed.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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