Drug interactions
Crizotinib + Temsirolimus
Severity: Moderate
Crizotinib and Temsirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib is a moderate CYP3A inhibitor and may raise exposure to temsirolimus and its active metabolite sirolimus. Higher exposure may increase mTOR-related adverse effects such as mucositis, hyperglycemia, hyperlipidemia, cytopenias and pneumonitis.
What this interaction means in plain words
Crizotinib and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Crizotinib belongs to Oncology; Temsirolimus belongs to Oncology.
Why it happens
Crizotinib inhibits CYP3A4-mediated metabolism of temsirolimus and sirolimus.
What to do
Monitor for temsirolimus toxicity such as mucositis, cytopenias, glucose and lipid abnormalities, and pulmonary symptoms. Consider dose reduction of temsirolimus if adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Crizotinib with Temsirolimus?
MediHelp rates the interaction as moderate. Crizotinib and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crizotinib is a moderate CYP3A inhibitor and may raise exposure to temsirolimus and its active metabolite sirolimus. Higher exposure may increase mTOR-related adverse effects such as mucositis, hyperglycemia, hyperlipidemia, cytopenias and pneumonitis.
How serious is the interaction between Crizotinib and Temsirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for temsirolimus toxicity such as mucositis, cytopenias, glucose and lipid abnormalities, and pulmonary symptoms. Consider dose reduction of temsirolimus if adverse effects emerge.
What other medicines interact with Temsirolimus?
MediHelp also lists interactions of Temsirolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Temsirolimus page.
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