Drug interactions
Crizotinib + Tiotropium-olodaterol
Severity: Moderate
Crizotinib and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib can prolong the QT interval and cause bradycardia, while olodaterol may add to arrhythmia risk through sympathetic stimulation and lowered potassium. The combined risk is greatest in patients with cardiac disease or electrolyte disturbances.
What this interaction means in plain words
Crizotinib and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Crizotinib belongs to Oncology; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Additive effects on cardiac repolarization together with beta2-mediated hypokalemia.
What to do
Monitor ECG and electrolytes periodically during combined use. Correct potassium and magnesium deficits and review other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium-olodaterol
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Crizotinib with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Crizotinib and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crizotinib can prolong the QT interval and cause bradycardia, while olodaterol may add to arrhythmia risk through sympathetic stimulation and lowered potassium. The combined risk is greatest in patients with cardiac disease or electrolyte disturbances.
How serious is the interaction between Crizotinib and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes periodically during combined use. Correct potassium and magnesium deficits and review other QT-prolonging drugs.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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