Drug interactions
Crizotinib + Trimipramine
Severity: Major
Crizotinib and Trimipramine: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib can prolong the QT interval and cause bradycardia, and trimipramine adds further QT liability. Crizotinib also inhibits CYP3A4, which may raise trimipramine exposure and its toxicity.
What this interaction means in plain words
Crizotinib and Trimipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Crizotinib belongs to Oncology; Trimipramine belongs to Central Nervous System.
Why it happens
Additive QT prolongation plus crizotinib inhibition of CYP3A4-mediated trimipramine metabolism.
What to do
Obtain a baseline ECG, correct potassium and magnesium, and repeat ECGs during co-therapy. Consider an alternative antidepressant, or reduce the trimipramine dose and monitor for tricyclic toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Crizotinib with Trimipramine?
MediHelp rates the interaction as major. Crizotinib and Trimipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Crizotinib can prolong the QT interval and cause bradycardia, and trimipramine adds further QT liability. Crizotinib also inhibits CYP3A4, which may raise trimipramine exposure and its toxicity.
How serious is the interaction between Crizotinib and Trimipramine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG, correct potassium and magnesium, and repeat ECGs during co-therapy. Consider an alternative antidepressant, or reduce the trimipramine dose and monitor for tricyclic toxicity.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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