Drug interactions
Crofelemer + Dasatinib
Severity: Minor
Crofelemer and Dasatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crofelemer is minimally absorbed but may inhibit CYP3A4 in the gut. A small rise in dasatinib exposure is theoretically possible but unlikely to be clinically important.
What this interaction means in plain words
Crofelemer and Dasatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Crofelemer belongs to Gastrointestinal Tract; Dasatinib belongs to Oncology.
Why it happens
Intestinal CYP3A4 inhibition by crofelemer may reduce first-pass dasatinib metabolism.
What to do
No routine adjustment. Monitor for dasatinib adverse effects such as cytopenias or fluid retention.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Other interactions of Crofelemer
- Crofelemer + Ergotamine Moderate
- Alfuzosin + Crofelemer Minor
- Amiodarone + Crofelemer Minor
- Apixaban + Crofelemer Minor
- Aprepitant + Crofelemer Minor
- Armodafinil + Crofelemer Minor
Frequently asked questions
Can I take Crofelemer with Dasatinib?
MediHelp rates the interaction as minor. Crofelemer and Dasatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Crofelemer is minimally absorbed but may inhibit CYP3A4 in the gut. A small rise in dasatinib exposure is theoretically possible but unlikely to be clinically important.
How serious is the interaction between Crofelemer and Dasatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment. Monitor for dasatinib adverse effects such as cytopenias or fluid retention.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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