Drug interactions
Crofelemer + Eplerenone
Severity: Minor
Crofelemer and Eplerenone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crofelemer is minimally absorbed and may inhibit CYP3A4 in the gut in vitro. The effect on systemic eplerenone exposure is likely small and has not been shown to be clinically relevant.
What this interaction means in plain words
Crofelemer and Eplerenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Crofelemer belongs to Gastrointestinal Tract; Eplerenone belongs to Cardiovascular.
Why it happens
Possible intestinal CYP3A4 inhibition by crofelemer, reducing first-pass metabolism of eplerenone.
What to do
No routine adjustment is needed; monitor serum potassium and blood pressure if eplerenone effects appear exaggerated.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Eplerenone
- Amiloride + Eplerenone Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Clarithromycin + Eplerenone Contraindicated
- Cobicistat + Eplerenone Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Eplerenone Contraindicated
- Ensitrelvir + Eplerenone Contraindicated
Other interactions of Crofelemer
- Crofelemer + Ergotamine Moderate
- Alfuzosin + Crofelemer Minor
- Amiodarone + Crofelemer Minor
- Apixaban + Crofelemer Minor
- Aprepitant + Crofelemer Minor
- Armodafinil + Crofelemer Minor
Frequently asked questions
Can I take Crofelemer with Eplerenone?
MediHelp rates the interaction as minor. Crofelemer and Eplerenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Crofelemer is minimally absorbed and may inhibit CYP3A4 in the gut in vitro. The effect on systemic eplerenone exposure is likely small and has not been shown to be clinically relevant.
How serious is the interaction between Crofelemer and Eplerenone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor serum potassium and blood pressure if eplerenone effects appear exaggerated.
What other medicines interact with Eplerenone?
MediHelp also lists interactions of Eplerenone with, for example, Amiloride, Atazanavir, Clarithromycin. The full list is on the Eplerenone page.
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