Drug interactions
Crofelemer + Flibanserin
Severity: Minor
Crofelemer and Flibanserin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crofelemer is minimally absorbed and its CYP3A4 inhibition is shown in vitro at gut concentrations, with no established clinical effect on flibanserin.
What this interaction means in plain words
Crofelemer and Flibanserin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Crofelemer belongs to Gastrointestinal Tract; Flibanserin belongs to Genitourinary.
Why it happens
Possible intestinal CYP3A4 inhibition, not clinically established.
What to do
Monitor for flibanserin adverse effects such as dizziness and somnolence.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Other interactions of Crofelemer
- Crofelemer + Ergotamine Moderate
- Alfuzosin + Crofelemer Minor
- Amiodarone + Crofelemer Minor
- Apixaban + Crofelemer Minor
- Aprepitant + Crofelemer Minor
- Armodafinil + Crofelemer Minor
Frequently asked questions
Can I take Crofelemer with Flibanserin?
MediHelp rates the interaction as minor. Crofelemer and Flibanserin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Crofelemer is minimally absorbed and its CYP3A4 inhibition is shown in vitro at gut concentrations, with no established clinical effect on flibanserin.
How serious is the interaction between Crofelemer and Flibanserin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for flibanserin adverse effects such as dizziness and somnolence.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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