Drug interactions
Crofelemer + Lurasidone
Severity: Minor
Crofelemer and Lurasidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crofelemer is minimally absorbed and may inhibit CYP3A4 only in the gut lumen. Any increase in lurasidone exposure is theoretical and probably small, though lurasidone is sensitive to CYP3A4 inhibition.
What this interaction means in plain words
Crofelemer and Lurasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Crofelemer belongs to Gastrointestinal Tract; Lurasidone belongs to Central Nervous System.
Why it happens
Possible local intestinal CYP3A4 inhibition by crofelemer reducing first-pass metabolism of lurasidone.
What to do
No routine dose change is needed. Watch for lurasidone adverse effects such as akathisia, sedation or parkinsonism.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Crofelemer
- Crofelemer + Ergotamine Moderate
- Alfuzosin + Crofelemer Minor
- Amiodarone + Crofelemer Minor
- Apixaban + Crofelemer Minor
- Aprepitant + Crofelemer Minor
- Armodafinil + Crofelemer Minor
Frequently asked questions
Can I take Crofelemer with Lurasidone?
MediHelp rates the interaction as minor. Crofelemer and Lurasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Crofelemer is minimally absorbed and may inhibit CYP3A4 only in the gut lumen. Any increase in lurasidone exposure is theoretical and probably small, though lurasidone is sensitive to CYP3A4 inhibition.
How serious is the interaction between Crofelemer and Lurasidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Watch for lurasidone adverse effects such as akathisia, sedation or parkinsonism.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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