Drug interactions
Crofelemer + Mefloquine
Severity: Minor
Crofelemer and Mefloquine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crofelemer may inhibit CYP3A4 locally in the gut, but systemic absorption is minimal. A clinically meaningful rise in mefloquine levels is unlikely.
What this interaction means in plain words
Crofelemer and Mefloquine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Crofelemer belongs to Gastrointestinal Tract; Mefloquine belongs to Anti Parasitic.
Why it happens
Possible intestinal CYP3A4 inhibition by crofelemer.
What to do
No dose adjustment is needed. Monitor for mefloquine neuropsychiatric effects if symptoms occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Other interactions of Crofelemer
- Crofelemer + Ergotamine Moderate
- Alfuzosin + Crofelemer Minor
- Amiodarone + Crofelemer Minor
- Apixaban + Crofelemer Minor
- Aprepitant + Crofelemer Minor
- Armodafinil + Crofelemer Minor
Frequently asked questions
Can I take Crofelemer with Mefloquine?
MediHelp rates the interaction as minor. Crofelemer and Mefloquine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Crofelemer may inhibit CYP3A4 locally in the gut, but systemic absorption is minimal. A clinically meaningful rise in mefloquine levels is unlikely.
How serious is the interaction between Crofelemer and Mefloquine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor for mefloquine neuropsychiatric effects if symptoms occur.
What other medicines interact with Mefloquine?
MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Mefloquine page.
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