Drug interactions
Crofelemer + Saxagliptin
Severity: Minor
Crofelemer and Saxagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crofelemer may inhibit CYP3A4 locally in the gut, which could modestly raise saxagliptin exposure. Because crofelemer is barely absorbed, systemic inhibition is unlikely and the clinical effect is probably small.
What this interaction means in plain words
Crofelemer and Saxagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Crofelemer belongs to Gastrointestinal Tract; Saxagliptin belongs to Endocrine.
Why it happens
Possible inhibition of intestinal CYP3A4 by crofelemer, reducing first-pass metabolism of saxagliptin.
What to do
No dose change is normally needed; monitor glycemic control and watch for saxagliptin adverse effects if both are used long term.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Crofelemer and Saxagliptin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Saxagliptin
- Albiglutide + Saxagliptin Moderate
- Amlodipine-benazepril + Saxagliptin Moderate
- Aripiprazole + Saxagliptin Moderate
- Asenapine + Saxagliptin Moderate
- Atazanavir + Saxagliptin Moderate
- Benazepril + Saxagliptin Moderate
Other interactions of Crofelemer
- Crofelemer + Ergotamine Moderate
- Alfuzosin + Crofelemer Minor
- Amiodarone + Crofelemer Minor
- Apixaban + Crofelemer Minor
- Aprepitant + Crofelemer Minor
- Armodafinil + Crofelemer Minor
Frequently asked questions
Can I take Crofelemer with Saxagliptin?
MediHelp rates the interaction as minor. Crofelemer and Saxagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Crofelemer may inhibit CYP3A4 locally in the gut, which could modestly raise saxagliptin exposure. Because crofelemer is barely absorbed, systemic inhibition is unlikely and the clinical effect is probably small.
How serious is the interaction between Crofelemer and Saxagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is normally needed; monitor glycemic control and watch for saxagliptin adverse effects if both are used long term.
What other medicines interact with Saxagliptin?
MediHelp also lists interactions of Saxagliptin with, for example, Albiglutide, Amlodipine-benazepril, Aripiprazole. The full list is on the Saxagliptin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
